Bioactivity of two Turkish endemic Centaurea species, and their major constituents

The antioxidant activity, general toxicity and cytotoxicity of the methanol extracts of Centaurea urvillei subs. armata and C. mucronifera have been assessed, respectively, by the DPPH assay, the brine shrimp lethality and the MTT cytotoxicity assays. The reversed-phase HPLC analysis of the methanol...

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Published inRevista brasileira de farmacognosia Vol. 17; no. 2; pp. 155 - 159
Main Authors Shoeb, Mohammad, MacManus, Stephen M., Jaspars, Marcel, Kong-Thoo-Lin, Paul, Nahar, Lutfun, Celik, Sezgin, Sarker, Satyajit D.
Format Journal Article
LanguageEnglish
Portuguese
Published Sociedade Brasileira de Farmacognosia 01.06.2007
Subjects
PHARMACOLOGY & PHARMACY
arctiin
Artemia salina
Centaurea mucronifera
DPPH
toxicidade
matairesinosídeo
arctiina
matairesinoside
Compositae
MTT
Centaurea urvillei subs. armata
lignan
brine shrimp lethality assay
Asteraceae
lignana
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Summary:The antioxidant activity, general toxicity and cytotoxicity of the methanol extracts of Centaurea urvillei subs. armata and C. mucronifera have been assessed, respectively, by the DPPH assay, the brine shrimp lethality and the MTT cytotoxicity assays. The reversed-phase HPLC analysis of the methanol extracts afforded two bioactive dibenzylbutyrolactone-type lignans, matairesinoside (1) and arctiin (2). The structures of these lignans were elucidated by comprehensive spectroscopic analyses as well as by the direct comparison of experimental data with respective literature data.
ISSN:0102-695X
1981-528X
DOI:10.1590/S0102-695X2007000200003