Relationship between Apoptosis and E-cadherin Expression in Bronchial Epithelium of Smoking Mouse

• Published in: Current medical science Vol. 23; no. 3; pp. 216 - 218
• Main Author: 刘丽芳 袁永辉 李钫 刘红云
• Format: Journal Article
• Language: English
• Published: China Department of Pathology, School of Basic Medical Sciences, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030 2003
• Subjects: Animals; Apoptosis; Bronchi - metabolism; Bronchi - pathology; Cadherins - analysis; Cadherins - biosynthesis; E-钙粘素; Epithelial Cells - chemistry; Epithelial Cells - metabolism; Epithelial Cells - pathology; Mice; Smoking - adverse effects; 吸烟; 支气管上皮细胞; 细胞凋亡; apoptosis; E-cadherin; bronchial epithelia; smoking
• ISSN: 1672-0733; 2096-5230; 2523-899X
• DOI: 10.1007/BF02829495

To investigate whether apoptosis is associated with cell adhesion in bronchial epithelium,and whether it contributes to the kinetics of injury and repair of surface epithelia, this study was performed for E-cadherin expression by using immunohistochemistry technique and for apoptosis by TUNEL method. An animal model of smoking was used for this study. The results showed that epithelial cells with membrane anchored E-cadherin decreased remarkably at several time points during 6 months of exposure to smoke (P<0. 01) and then restored to normal level. This fluctuation was associated exclusively with the alteration in number of apoptotic cells (P<0. 01). There wasno significant difference in activation of nuclear transcription factor NF-kappa B among groups (P>0. 05). All these suggested that apoptosis is associated with E-cadherin expression in bronchial epithelium of smoking mouse.