In vitro transformation of hamster embryo cells by bovine adenovirus type 3 (strain WBR-1)

Division of Experimental Biology Baylor College of Medicine, Houston, Texas 77025, U.S.A. Bovine adenovirus type 3 (BAV-3), strain WBR-1, quantitatively transforms hamster embryo carcass cells with a maximum efficiency of 4.7 x 10 4 p.f.u./focus-forming units (f.f.u.). This frequency is significantl...

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Bibliographic Details
Published inJournal of general virology Vol. 26; no. 1; pp. 141 - 143
Main Authors Panigrahy, B, McCormick, K.J, Stenback, W.A, Trentin, J.J
Format Journal Article
LanguageEnglish
Published Soc General Microbiol 1975
Subjects
animal diseases
animal health
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Summary:Division of Experimental Biology Baylor College of Medicine, Houston, Texas 77025, U.S.A. Bovine adenovirus type 3 (BAV-3), strain WBR-1, quantitatively transforms hamster embryo carcass cells with a maximum efficiency of 4.7 x 10 4 p.f.u./focus-forming units (f.f.u.). This frequency is significantly inhibited by the presence of 1.8 m M of Ca ++ . The transformed cells are highly tumourigenic in hamsters and possess T- and tumour-specific transplantation antigens. BAV-3 is one of the most oncogenic of the adenoviruses and an ideal model virus for the study of transformation. Received 13 August 1974; accepted 19 September 1974.
ISSN:0022-1317
1465-2099
DOI:10.1099/0022-1317-26-1-141