In vitro transformation of hamster embryo cells by bovine adenovirus type 3 (strain WBR-1)
Division of Experimental Biology Baylor College of Medicine, Houston, Texas 77025, U.S.A. Bovine adenovirus type 3 (BAV-3), strain WBR-1, quantitatively transforms hamster embryo carcass cells with a maximum efficiency of 4.7 x 10 4 p.f.u./focus-forming units (f.f.u.). This frequency is significantl...
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Published in | Journal of general virology Vol. 26; no. 1; pp. 141 - 143 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
Soc General Microbiol
1975
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Subjects | |
Online Access | Get full text |
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Summary: | Division of Experimental Biology Baylor College of Medicine, Houston, Texas 77025, U.S.A.
Bovine adenovirus type 3 (BAV-3), strain WBR-1, quantitatively transforms hamster embryo carcass cells with a maximum efficiency of 4.7 x 10 4 p.f.u./focus-forming units (f.f.u.). This frequency is significantly inhibited by the presence of 1.8 m M of Ca ++ . The transformed cells are highly tumourigenic in hamsters and possess T- and tumour-specific transplantation antigens. BAV-3 is one of the most oncogenic of the adenoviruses and an ideal model virus for the study of transformation.
Received 13 August 1974;
accepted 19 September 1974. |
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ISSN: | 0022-1317 1465-2099 |
DOI: | 10.1099/0022-1317-26-1-141 |