Indirect determination of the microsomal oxidase activity of hepatocytes and the effect of ximedone on this activity during streptococcal angina

The parameters of antipyrine pharmacokinetics in saliva have been calculated and a method for indirect determination of the microsomal oxidase activity of hepatocytes has been developed based on evaluation of the average content of the test compound in sequential 3-h samples of saliva taken over a 1...

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Published inPharmaceutical chemistry journal Vol. 42; no. 12; pp. 659 - 664
Main Authors Garmonov, S. Yu, Kravchenko, I. E, Shitova, N. S, Yakovleva, A. V, Zaripova, R. G, Fazylov, V. Kh
Format Journal Article
LanguageEnglish
Published Boston Boston : Springer US 01.12.2008
Springer US
Subjects
Medicine
Molecular-Biological Problems of Drug Design and Mechanism of Drug Action
Organic Chemistry
Pharmacology/Toxicology
Pharmacy
Streptococcus
Antipyrine
Drug Elimination
Phenazone
Test Tissue
Angina Patient
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Summary:The parameters of antipyrine pharmacokinetics in saliva have been calculated and a method for indirect determination of the microsomal oxidase activity of hepatocytes has been developed based on evaluation of the average content of the test compound in sequential 3-h samples of saliva taken over a 12-h period of time after administration. Microsomal oxidase activity has been estimated in patients wth streptococcal angina. It is established that ximedone effectvely influences this activity and produces a positive therapeutic effect on the course of the disorder.
Bibliography:http://dx.doi.org/10.1007/s11094-009-0219-x
ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ISSN:0091-150X
1573-9031
DOI:10.1007/s11094-009-0219-x