Nuclease activity of 2-substituted heteroaromatic thiosemicarbazone and semicarbazone copper(II) complexes

• Published in: Transition metal chemistry (Weinheim) Vol. 25; no. 2; pp. 154 - 160
• Main Authors: Hussain Reddy, K, Sambasiva Reddy, P, Babu, P Ravindra
• Format: Journal Article
• Language: English
• Published: Dordrecht Springer Nature B.V 01.04.2000
• Subjects: Electron transfer
• ISSN: 0340-4285; 1572-901X
• DOI: 10.1023/A:1007027011216

Copper(II) Schiff base complexes derived from furan-2-carboxaldehyde, 2-furylmethyl ketone, thiophene-2-carboxaldehyde and methyl-2-thienyl ketone with semicarbazide and thiosemicarbazide have been prepared and characterized by analytical, i.r., electronic, e.s.r. and c.v. spectral data. The electronic spectral d-d band position varies from 744-415nm in pyridine and 872-371nm in DMF. E.s.r. g^sub ^ values lie between 2.1439 and 2.3149 at LNT. All complexes undergo quasi-reversible one-electron electrochemical reduction (Cu^sup III^/Cu^sup II^) in the 0.42-0.52V potential range. The electron transfer is much faster in thiosemicarbazone complexes compared to semicarbazone complexes. All these copper(II) complexes showed increased nuclease activity in presence of oxidant.[PUBLICATION ABSTRACT]