Total synthesis of tumor-associated KH-1 antigen core nonasaccharide via photo-induced glycosylation

The synthesis of tumor-associated KH-1 antigen core nonasaccharide was achieved. All key glycosidic linkages were efficiently constructed by photo-induced glycosylation. The success of this total synthesis provides an example for the preparation of complex oligosaccharides using light-driven glycosy...

Full description

Saved in:
Bibliographic Details
Published inORGANIC CHEMISTRY FRONTIERS Vol. 7; no. 10; pp. 1255 - 1259
Main Authors Li, Bo-Han, Yao, Wenlong, Yang, Hong, Wu, Congying, Xiong, De-Cai, Yin, Yuxin, Ye, Xin-Shan
Format Journal Article
LanguageEnglish
Published CAMBRIDGE Royal Soc Chemistry 21.05.2020
Royal Society of Chemistry
Subjects
Antigens
Chemistry
Chemistry, Organic
Glycosylation
Oligosaccharides
Organic chemistry
Physical Sciences
Science & Technology
Synthesis
Tumors
ANTIBODIES
LEY
THIOGLYCOSIDES
ONE-POT SYNTHESIS
ADENOCARCINOMA
ALKYLATION
STEREOSELECTIVE-SYNTHESIS
IMMUNOLOGICAL EVALUATION
CANCER
ALTERED GLYCOSYLATION
Online AccessGet full text

Cover

More Information
Summary:The synthesis of tumor-associated KH-1 antigen core nonasaccharide was achieved. All key glycosidic linkages were efficiently constructed by photo-induced glycosylation. The success of this total synthesis provides an example for the preparation of complex oligosaccharides using light-driven glycosylation reactions.
ISSN:2052-4129
2052-4110
2052-4110
DOI:10.1039/d0qo00314j