Inhibitory Effect of Apernyl on Production of Bradykininlike Substance in Pulp

In the Formalin-induced pulpitis of rats and the electrically stimulated pulps of dogs, a bradykinin like substance developed by the pulps and released into a saline pool on the exposed pulps disappeared after a local application of Apernyl solution. This suggests that the possible pain-reducing or...

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Bibliographic Details
Published inJournal of dental research Vol. 54; no. 5; pp. 1082 - 1086
Main Authors Kudo, Teruo, Kawagoe, Masataka, Hayashi, Takeshi, Takezawa, Jun, Inoki, Reizo
Format Journal Article
LanguageEnglish
Published Los Angeles, CA SAGE Publications 01.09.1975
Subjects
Animals
Anti-Inflammatory Agents, Non-Steroidal - pharmacology
Aspirin - pharmacology
Biological Assay
Bradykinin - analysis
Bradykinin - metabolism
Dental Pulp - drug effects
Dental Pulp - metabolism
Dental Pulp Exposure
Depression, Chemical
Dogs
Drug Combinations
Electric Stimulation
Formaldehyde - adverse effects
Male
Parabens - pharmacology
Pulpitis - chemically induced
Pulpitis - metabolism
Rats
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Summary:In the Formalin-induced pulpitis of rats and the electrically stimulated pulps of dogs, a bradykinin like substance developed by the pulps and released into a saline pool on the exposed pulps disappeared after a local application of Apernyl solution. This suggests that the possible pain-reducing or anti-inflammatory effect of Apernyl is a result of its inhibiting bradykinin production.
ISSN:0022-0345
1544-0591
DOI:10.1177/00220345750540051301