SYNTHESIS OF NOVEL INHIBITORS OF ELECTRON-TRANSPORT

Molecular modelling comparisons of several known natural and synthetic inhibitors of electron transport, e.g. rotenone, papaverine, and piericidin A, suggested new 'hybrid' structures 8-12, and relatives, as potential new inhibitors. Synthetic routes to these targets, some of which display...

Full description

Saved in:
Bibliographic Details
Published inJournal of the Chemical Society, Perkin Transactions 1 no. 9; pp. 1103 - 1113
Main Authors COCKERILL, GS, LEVETT, PC, WHITING, DA
Format Journal Article
LanguageEnglish
Published CAMBRIDGE Royal Soc Chemistry 1995
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
SYSTEM
MYXOBACTERALES
ANTIBIOTICS
ROTENONE
GLIDING BACTERIA
Online AccessGet full text

Cover

More Information
Summary:Molecular modelling comparisons of several known natural and synthetic inhibitors of electron transport, e.g. rotenone, papaverine, and piericidin A, suggested new 'hybrid' structures 8-12, and relatives, as potential new inhibitors. Synthetic routes to these targets, some of which display significant biological activity, are outlined.
ISSN:1472-7781
0300-922X
1364-5463
DOI:10.1039/p19950001103