Visible-light-driven photoredox-catalyzed C(sp3)–C(sp3) cross-coupling of N-arylamines with cycloketone oxime esters

A novel photoredox-catalyzed C(sp3)–C(sp3) cross-coupling between N-arylamines and cycloketone oxime esters under mild conditions has been accomplished. The redox-neutral reaction proceeds with good functional group tolerance and excellent regioselectivity without any extra base or ligand control. I...

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Published inOrganic chemistry frontiers an international journal of organic chemistry Vol. 9; no. 9; pp. 2534 - 2540
Main Authors Sheng-Yun, Zhou, Zhang, Ding, Xiao-Jie, Liu, Jing-Hao, Qin, Zheng-Li, Fu, Shuang-Long, Li, Fang-Jun, Cai, Yang, Li, Jin-Heng, Li
Format Journal Article
LanguageEnglish
Published London Royal Society of Chemistry 03.05.2022
Subjects
Amines
Cross coupling
Esters
Functional groups
Organic chemistry
Organic compounds
Oxime esters
Peptides
Photoredox catalysis
Regioselectivity
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Summary:A novel photoredox-catalyzed C(sp3)–C(sp3) cross-coupling between N-arylamines and cycloketone oxime esters under mild conditions has been accomplished. The redox-neutral reaction proceeds with good functional group tolerance and excellent regioselectivity without any extra base or ligand control. In addition, this approach was successfully applied for the late-stage modification of short peptides and analogues.
ISSN:2052-4110
2052-4110
DOI:10.1039/d2qo00128d