Bilirubin–Albumin Binding and Free Bilirubin
The relevance of plasma bilirubin-albumin binding and, in particular, the nonalbumin-bound or "free" bilirubin concentration to neonatal bilirubin toxicity is controversial. The pivotal role that "free" bilirubin played in the bilirubin toxicity that occurred following administra...
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Published in | Journal of perinatology Vol. 21; no. S1; pp. S40 - S42 |
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Main Author | |
Format | Journal Article |
Language | English |
Published |
United States
Nature Publishing Group
01.12.2001
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Subjects | |
Online Access | Get full text |
ISSN | 0743-8346 1476-5543 |
DOI | 10.1038/sj.jp.7210631 |
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Abstract | The relevance of plasma bilirubin-albumin binding and, in particular, the nonalbumin-bound or "free" bilirubin concentration to neonatal bilirubin toxicity is controversial. The pivotal role that "free" bilirubin played in the bilirubin toxicity that occurred following administration of sulfisoxazole or benzyl alcohol to jaundiced newborns, and the correlation of "free" bilirubin with bilirubin-induced changes in the auditory brainstem response are strong support for measuring "free" bilirubin when evaluating neonatal jaundice. Reliable methods for measuring "free bilirubin" are available, and population reference values are needed to help determine its proper clinical use. |
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AbstractList | The relevance of plasma bilirubin-albumin binding and, in particular, the nonalbumin-bound or "free" bilirubin concentration to neonatal bilirubin toxicity is controversial. The pivotal role that "free" bilirubin played in the bilirubin toxicity that occurred following administration of sulfisoxazole or benzyl alcohol to jaundiced newborns, and the correlation of "free" bilirubin with bilirubin-induced changes in the auditory brainstem response are strong support for measuring "free" bilirubin when evaluating neonatal jaundice. Reliable methods for measuring "free bilirubin" are available, and population reference values are needed to help determine its proper clinical use.The relevance of plasma bilirubin-albumin binding and, in particular, the nonalbumin-bound or "free" bilirubin concentration to neonatal bilirubin toxicity is controversial. The pivotal role that "free" bilirubin played in the bilirubin toxicity that occurred following administration of sulfisoxazole or benzyl alcohol to jaundiced newborns, and the correlation of "free" bilirubin with bilirubin-induced changes in the auditory brainstem response are strong support for measuring "free" bilirubin when evaluating neonatal jaundice. Reliable methods for measuring "free bilirubin" are available, and population reference values are needed to help determine its proper clinical use. The relevance of plasma bilirubin-albumin binding and, in particular, the nonalbumin-bound or "free" bilirubin concentration to neonatal bilirubin toxicity is controversial. The pivotal role that "free" bilirubin played in the bilirubin toxicity that occurred following administration of sulfisoxazole or benzyl alcohol to jaundiced newborns, and the correlation of "free" bilirubin with bilirubin-induced changes in the auditory brainstem response are strong support for measuring "free" bilirubin when evaluating neonatal jaundice. Reliable methods for measuring "free bilirubin" are available, and population reference values are needed to help determine its proper clinical use. |
Author | Ahlfors, Charles E |
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References | MA Pearlman (BF7210631_CR2) 1978; 62 W Cashore (BF7210631_CR13) 1978; 93 BF7210631_CR3 CE Ahlfors (BF7210631_CR17) 2001; 139 PJ Robinson (BF7210631_CR4) 1987; 79 RC Harris (BF7210631_CR7) 1958; 21 SB Amin (BF7210631_CR21) 2001; 107 CE Ahlfors (BF7210631_CR22) 2000; 279 RL Levine (BF7210631_CR14) 1982; 69 BM Crosse (BF7210631_CR5) 1955; 30 GB Odell (BF7210631_CR9) 1959; 38 CE Ahlfors (BF7210631_CR10) 2000; 137 L Johnson (BF7210631_CR11) 1959; 97 R Brodersen (BF7210631_CR8) 1979; 254 WJ Brown (BF7210631_CR15) 1982; 1 RP Wennberg (BF7210631_CR19) 1986; 20 D Trolle (BF7210631_CR6) 1961; 50 R Shimabuku (BF7210631_CR12) 1982; 28 DA Ritter (BF7210631_CR16) 1982; 69 M Perlman (BF7210631_CR1) 1988; 81 M Funato (BF7210631_CR20) 1994; 93 H Nakamura (BF7210631_CR18) 1992; 34 |
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SubjectTerms | Albumin Albumins Alcohol Anti-Infective Agents - adverse effects Benzyl alcohol Bilirubin Bilirubin - metabolism Binding Brain stem Humans Hypotheses Infant, Newborn Jaundice Kernicterus - metabolism Kernicterus - physiopathology Light therapy Measurement methods Metabolism Neonates Pathophysiology Pediatrics Plasma Protein Binding Risk Factors Serum Albumin - metabolism Sulfamethoxazole - adverse effects Sulfisoxazole Toxicity |
Title | Bilirubin–Albumin Binding and Free Bilirubin |
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