Bilirubin–Albumin Binding and Free Bilirubin

The relevance of plasma bilirubin-albumin binding and, in particular, the nonalbumin-bound or "free" bilirubin concentration to neonatal bilirubin toxicity is controversial. The pivotal role that "free" bilirubin played in the bilirubin toxicity that occurred following administra...

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Bibliographic Details
Published inJournal of perinatology Vol. 21; no. S1; pp. S40 - S42
Main Author Ahlfors, Charles E
Format Journal Article
LanguageEnglish
Published United States Nature Publishing Group 01.12.2001
Subjects
Albumin
Albumins
Alcohol
Anti-Infective Agents - adverse effects
Benzyl alcohol
Bilirubin
Bilirubin - metabolism
Binding
Brain stem
Humans
Hypotheses
Infant, Newborn
Jaundice
Kernicterus - metabolism
Kernicterus - physiopathology
Light therapy
Measurement methods
Metabolism
Neonates
Pathophysiology
Pediatrics
Plasma
Protein Binding
Risk Factors
Serum Albumin - metabolism
Sulfamethoxazole - adverse effects
Sulfisoxazole
Toxicity
United States > US
San Francisco California
California
Online AccessGet full text
ISSN0743-8346
1476-5543
DOI10.1038/sj.jp.7210631

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Summary:The relevance of plasma bilirubin-albumin binding and, in particular, the nonalbumin-bound or "free" bilirubin concentration to neonatal bilirubin toxicity is controversial. The pivotal role that "free" bilirubin played in the bilirubin toxicity that occurred following administration of sulfisoxazole or benzyl alcohol to jaundiced newborns, and the correlation of "free" bilirubin with bilirubin-induced changes in the auditory brainstem response are strong support for measuring "free" bilirubin when evaluating neonatal jaundice. Reliable methods for measuring "free bilirubin" are available, and population reference values are needed to help determine its proper clinical use.
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ISSN:0743-8346
1476-5543
DOI:10.1038/sj.jp.7210631