Brain Mineralocorticoid Receptors and Resilience to Stress

Exposure to stressful experiences triggers the release of-among others-glucocorticoids from the adrenal glands. These hormones, cortisol and corticosterone in humans and rodents respectively, activate mineralocorticoid receptors (MRs) and glucocorticoid receptors (GRs) that regulate neuronal activit...

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Bibliographic Details
Published inVitamins and hormones Vol. 109; pp. 341 - 359
Main Authors Kanatsou, Sofia, Joels, Marian, Krugers, Harm
Format Journal Article
LanguageEnglish
Published United States 2019
Subjects
Early life adversity
Chronic stress
Cortisol
Corticosterone
Memory
Depression electrophysiology
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Summary:Exposure to stressful experiences triggers the release of-among others-glucocorticoids from the adrenal glands. These hormones, cortisol and corticosterone in humans and rodents respectively, activate mineralocorticoid receptors (MRs) and glucocorticoid receptors (GRs) that regulate neuronal activity and behavioral adaptation to stressful experiences. This review discusses molecular properties of MRs, the role of MRs in regulating neuronal function and behavior and, ultimately, evidence that enhanced MR function may confer resilience to stressful experiences.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:0083-6729
DOI:10.1016/bs.vh.2018.11.001