Structural Modification of the Immunosuppressants FK-506 and Ascomycin Using a Biological Approach

Bioconversion was utilized to conduct structural modification of the complex molecules FK-506 and ascomycin. Four interesting microbial reactions, regiospecific O-demethylation, glucosylation, hydroxylation, and phosphorylation, yielding various derivatives of the title compounds, were discovered fr...

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Bibliographic Details
Published inChimia Vol. 53; no. 12
Main Authors Tom S. Chen, Xiaohua Li, Brian Petuch, Ali Shafiee, Lydia So
Format Journal Article
LanguageGerman
Published Swiss Chemical Society 01.01.1999
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Summary:Bioconversion was utilized to conduct structural modification of the complex molecules FK-506 and ascomycin. Four interesting microbial reactions, regiospecific O-demethylation, glucosylation, hydroxylation, and phosphorylation, yielding various derivatives of the title compounds, were discovered from screening more than thousand microorganisms including bacteria, actinomycetes, and fungi. The isolated compounds were evaluated for a better understanding of structural and functional features responsible for their biological activity.
ISSN:0009-4293
2673-2424
DOI:10.2533/chimia.1999.596