Solid and solution phase syntheses of the 2-cyanopyrrolidide DPP-IV inhibitor NVP-DPP728

DPP-IV inhibitors have been suggested as potential new treatments for type-II diabetes and 2-cyanopyrrolidides have been reported as potent DPP-IV inhibitors. Alternative synthetic approaches to one such compound, NVP-DPP728, are investigated here. One strategy is based in solution phase and is amen...

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Bibliographic Details
Published inTetrahedron Vol. 58; no. 28; pp. 5741 - 5746
Main Authors Willand, Nicolas, Joossens, Jurgen, Gesquière, Jean-Claude, Tartar, André L, Evans, D.Michael, Roe, Michael B
Format Journal Article
LanguageEnglish
Published Elsevier Ltd 2002
Elsevier
Subjects
cyanopyrrolidide
DPP-IV inhibitor
Life Sciences
NVP-DPP728
Pharmaceutical sciences
NVP-DPP728
cyanopyrrolidide
DPP-IV inhibitor
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Summary:DPP-IV inhibitors have been suggested as potential new treatments for type-II diabetes and 2-cyanopyrrolidides have been reported as potent DPP-IV inhibitors. Alternative synthetic approaches to one such compound, NVP-DPP728, are investigated here. One strategy is based in solution phase and is amenable to scale-up. The other is based on solid phase and is appropriate for the rapid analoging of the structural series. Alternative synthetic approaches to NVP-DPP728 are reported.
ISSN:0040-4020
1464-5416
DOI:10.1016/S0040-4020(02)00536-7