Synthesis of 2-pyrrolidinone derivatives via N-heterocyclic carbene catalyzed radical tandem cyclization/coupling reactions
Herein, a practical, convenient and facile protocol for constructing highly functionalized 2-pyrrolidinone enabled by N-heterocyclic carbene (NHC)-catalyzed radical tandem cyclization has been developed (30 examples, up to 94% yield). This method is transition metal free, and shows broad substrate s...
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Published in | ORGANIC CHEMISTRY FRONTIERS Vol. 10; no. 11; pp. 2695 - 2700 |
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Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
Published |
CAMBRIDGE
Royal Soc Chemistry
30.05.2023
Royal Society of Chemistry |
Subjects | |
Online Access | Get full text |
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Summary: | Herein, a practical, convenient and facile protocol for constructing highly functionalized 2-pyrrolidinone enabled by N-heterocyclic carbene (NHC)-catalyzed radical tandem cyclization has been developed (30 examples, up to 94% yield). This method is transition metal free, and shows broad substrate scope with excellent functional group compatibility and high efficiency. |
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ISSN: | 2052-4129 2052-4110 2052-4110 |
DOI: | 10.1039/d3qo00544e |