Synthesis of 2-pyrrolidinone derivatives via N-heterocyclic carbene catalyzed radical tandem cyclization/coupling reactions

Herein, a practical, convenient and facile protocol for constructing highly functionalized 2-pyrrolidinone enabled by N-heterocyclic carbene (NHC)-catalyzed radical tandem cyclization has been developed (30 examples, up to 94% yield). This method is transition metal free, and shows broad substrate s...

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Bibliographic Details
Published inORGANIC CHEMISTRY FRONTIERS Vol. 10; no. 11; pp. 2695 - 2700
Main Authors Yin, Huiping, Huang, Tianjiao, Shi, Bai, Cao, Wei, Yu, Chenxia, Li, Tuanjie, Zhang, Kai, Yao, Changsheng
Format Journal Article
LanguageEnglish
Published CAMBRIDGE Royal Soc Chemistry 30.05.2023
Royal Society of Chemistry
Subjects
Carbenes
Cascade chemical reactions
Chemical reactions
Chemistry
Chemistry, Organic
Functional groups
Organic chemistry
Physical Sciences
Science & Technology
Substrates
Transition metals
C-H ALKYLATION
ENANTIOSELECTIVE SYNTHESIS
MECHANISM
CONSTRUCTION
GAMMA-LACTAMS
BIOLOGICAL IMPORTANCE
ALDEHYDES
INHIBITORS
PYRROLIDINONE
AMIDES
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Summary:Herein, a practical, convenient and facile protocol for constructing highly functionalized 2-pyrrolidinone enabled by N-heterocyclic carbene (NHC)-catalyzed radical tandem cyclization has been developed (30 examples, up to 94% yield). This method is transition metal free, and shows broad substrate scope with excellent functional group compatibility and high efficiency.
ISSN:2052-4129
2052-4110
2052-4110
DOI:10.1039/d3qo00544e