Nuclease activity of mixed ligand complexes of copper(II) with heteroaromatic derivatives and picoline

• Published in: Transition metal chemistry (Weinheim) Vol. 25; no. 5; pp. 505 - 510
• Main Authors: Reddy, K Hussain, Reddy, P Sambasiva, Babu, P Ravindra
• Format: Journal Article
• Language: English
• Published: Dordrecht Springer Nature B.V 01.10.2000
• Subjects: Deoxyribonucleic acid; DNA
• ISSN: 0340-4285; 1572-901X
• DOI: 10.1023/A:1007038514536

New picoline adducts with carbamic acid [(furan-2-yl)methylene]hydrazide-Cu^sup II^ (CFMH) (1); thiocarbamic acid [(furan-2-yl)methylene]hydrazide-Cu^sup II^ (TFMH) (2); carbamic acid [(furan-2-yl)ethylidene]hydrazide-Cu^sup II^ (CFEH) (3), thiocarbamic acid [(furan-2-yl)ethylidene]hydrazide-Cu^sup II^ (TFEH) (4); carbamic acid [(thiophene-2-yl) methylene]hydrazide-Cu^sup II^ (CTMH) (5), thiocarbamic acid [(thiophene-2-yl)methylene]hydrazide-Cu^sup II^ (TTMH) (6), carbamic acid [(thiophene-2-yl)ethylidene]hydrazide-Cu^sup II^ (CTEH) (7), thiocarbamic acid [(thiophene-2-yl)ethylidene]hydrazide-Cu^sup II^ (TTEH) (8) have been prepared and characterized by analytical, i.r., electronic, e.s.r. and c.v. spectral data. The electronic spectra suggest distorted octahedral geometry for all the picoline adducts. E.s.r. g^sub ^ values lie between 2.251-2.286 at l.n.t. All the adducts undergo a quasi-reversible one-electron reduction in the range +0.47 to +0.51 V versus s.c.e., attributable to the Cu^sup III^/Cu^sup II^ redox couple. The electron transfer is much faster in the semicarbazone complexes than in the thiosemicarbazone complexes. All adducts showed increased nuclease activity in the presence of oxidant; the nuclease activity is compared with that of the parent copper(II) complexes.[PUBLICATION ABSTRACT]