Tying peptide ropes

Although the natural lasso peptide microcin J25 remains an elusive target for total chemical synthesis itself, this topologically non-trivial building block has now been used to construct a range of interlocked molecular architectures including rotaxanes, catenanes and daisy chains.

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Bibliographic Details
Published inNature chemistry Vol. 13; no. 9; pp. 822 - 823
Main Author van Maarseveen, Jan H.
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group 01.09.2021
Subjects
Chemical synthesis
Microcin J25
Molecular structure
Peptides
Rotaxanes
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Summary:Although the natural lasso peptide microcin J25 remains an elusive target for total chemical synthesis itself, this topologically non-trivial building block has now been used to construct a range of interlocked molecular architectures including rotaxanes, catenanes and daisy chains.
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ISSN:1755-4330
1755-4349
DOI:10.1038/s41557-021-00771-6