Design and Analysis of a Slotted Micro-cantilever based Biosensor for Detection of P24 Antigen in HIV Diagnoses

This paper presents the design and simulation of a slotted micro-cantilever based biosensor for HIV (Human Immune Deficiency Virus) detection with P-24 antigen. In this work, dynamic mode analysis is performed to study the frequency and the deflection of the micro-cantilever. The design procedure an...

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Bibliographic Details
Published in2020 IEEE Region 10 Symposium (TENSYMP) pp. 1400 - 1403
Main Authors Sarker, Tasnim, Samad, Mst. Fateha, Samad, Mst Fateha
Format Conference Proceeding
LanguageEnglish
Published IEEE 05.06.2020
Subjects
Biosensors
Diseases
displacement
dynamic mode
HIV
Human immunodeficiency virus
Immune system
Micro-cantilever
Micromechanical devices
P-24 antigen
slots
Structural beams
Viruses (medical)
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Summary:This paper presents the design and simulation of a slotted micro-cantilever based biosensor for HIV (Human Immune Deficiency Virus) detection with P-24 antigen. In this work, dynamic mode analysis is performed to study the frequency and the deflection of the micro-cantilever. The design procedure and finite element analysis of the model are conducted by COMSOL Multiphysics 5.4 software. The model of the micro-cantilever is multilayered which contains seven slots. The antibody coating on the cantilever surface interacts the present antigen of P-24 in the blood sample which deflects the body of the micro-cantilever. The simulated result shows a significant change in the displacement of the cantilever which results in a better sensitivity. It is observed that the displacement of the proposed model is as 3.47×10 6 μm.
ISSN:2642-6102
DOI:10.1109/TENSYMP50017.2020.9230768