Ring-opening/annulation reaction of cyclopropyl ethanols: concise access to thiophene aldehydes via C-S bond formation
The synthesis of thiophene aldehydes from easily available cyclopropyl ethanol derivatives and potassium sulfide has been developed. This novel one-pot procedure achieves double C-S bond formation via the cleavage of C-C bonds. This transformation shows good functional group tolerance under mild rea...
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Published in | ORGANIC CHEMISTRY FRONTIERS Vol. 6; no. 21; pp. 3705 - 3709 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
Published |
CAMBRIDGE
Royal Soc Chemistry
07.11.2019
Royal Society of Chemistry |
Subjects | |
Online Access | Get full text |
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Summary: | The synthesis of thiophene aldehydes from easily available cyclopropyl ethanol derivatives and potassium sulfide has been developed. This novel one-pot procedure achieves double C-S bond formation via the cleavage of C-C bonds. This transformation shows good functional group tolerance under mild reaction conditions. Moreover, DMSO acts as the solvent and mild oxidant simultaneously in this reaction. |
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ISSN: | 2052-4129 2052-4110 2052-4110 |
DOI: | 10.1039/c9qo01014a |