Polyoxygenated meroterpenoids and a bioactive illudalane derivative from a co-culture of Armillaria sp. and Epicoccum sp

Three novel polyoxygenated meroterpenoids, epiterenoids A-C (1-3), and a new illudalane derivative, armiloid A (4), were isolated from a liquid co-culture of Armillaria sp. and the endophytic fungus Epicoccum sp. YUD17002 associated with Gastrodia elata. Their structures were established by extensiv...

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Published inORGANIC CHEMISTRY FRONTIERS Vol. 6; no. 23; pp. 3847 - 3853
Main Authors Li, Hong-Tao, Tang, Linhuan, Liu, Tao, Yang, Ruining, Yang, Yabin, Zhou, Hao, Ding, Zhong-Tao
Format Journal Article
LanguageEnglish
Published CAMBRIDGE Royal Soc Chemistry 07.12.2019
Royal Society of Chemistry
Subjects
Chemistry
Chemistry, Organic
Crystal structure
Crystallography
Endophytes
Epicoccum
Fungi
NMR
Nuclear magnetic resonance
Organic chemistry
Physical Sciences
Science & Technology
PROTOILLUDANE
METABOLITES
FUNGI
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Summary:Three novel polyoxygenated meroterpenoids, epiterenoids A-C (1-3), and a new illudalane derivative, armiloid A (4), were isolated from a liquid co-culture of Armillaria sp. and the endophytic fungus Epicoccum sp. YUD17002 associated with Gastrodia elata. Their structures were established by extensive spectroscopic analyses, X-ray crystal diffraction, and TDDFT-ECD calculations. Compounds 1-3 possessed a 5/6/4/5/5-fused pentacyclic ring scaffold. Plausible biosynthetic pathways for 1-4 are proposed. Compound 4 exhibited potent AChE inhibitory activity, with an IC50 value of 4.91 mu M.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:2052-4129
2052-4110
2052-4110
DOI:10.1039/c9qo01087d