Multifunctional polyphosphazene-coated multi-walled carbon nanotubes for the synergistic treatment of redox-responsive chemotherapy and effective photothermal therapy

It is a long-pursued goal to improve the antitumor efficiency while decreasing the systemic side effects of therapeutic agents of cancers. In this study, a multifunctional drug delivery system (DDS) for chemo-photothermal therapeutics was developed by coating an anticancer-drug-containing polyphosph...

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Published inPolymer chemistry Vol. 8; no. 45; pp. 6938 - 6942
Main Authors Wang, Daquan, Ren, Yibo, Shao, Yongping, Meng, Lingjie
Format Journal Article
LanguageEnglish
Published Cambridge Royal Society of Chemistry 07.12.2017
Subjects
Chemical compounds
Chemotherapy
Doxorubicin
Drug delivery systems
Multi wall carbon nanotubes
Nanotubes
Pharmacology
Photothermal conversion
Polymer chemistry
Side effects
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Summary:It is a long-pursued goal to improve the antitumor efficiency while decreasing the systemic side effects of therapeutic agents of cancers. In this study, a multifunctional drug delivery system (DDS) for chemo-photothermal therapeutics was developed by coating an anticancer-drug-containing polyphosphazene (PPZ) onto multi-walled carbon nanotubes (MWNTs) via one-pot in situ polymerization of doxorubicin (DOX) and bis-(4-hydroxyphenyl)-disulfide (HPS) with hexachlorocyclotriphosphazene. The DOX loading ratio and release rate were precisely tuned via the adjustment of the DOX to HPS molar ratio. MWNTs were used as a nanotemplate and near-infrared photothermal conversion agent for effective photothermal therapy. Remarkably, this multifunctional DDS selectively suppressed and killed cancer cells, but negligibly affected normal cells. Hence, this DDS demonstrates the proof-of-concept for effective chemo-photothermal synergistic therapy.
ISSN:1759-9954
1759-9962
DOI:10.1039/C7PY01485F