Surgical Indications of Renovascular Hypertension : PANEL DISCUSSION ON DIAGNOSIS AND TREATMENT OF SECONDARY HYPERTENSION

Surgical indications on renovascular hypertension, especially on the patients in chronic stage with low plasma renin activity, have not been settled yet. To solve this problem, the Goldblatt's hypertensive dogs were subjected to successful renal homotransplantation or renal artery reconstructio...

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Published inJAPANESE CIRCULATION JOURNAL Vol. 37; no. 9; pp. 1049 - 1055
Main Authors WADA, TATSUO, MATSUMOTO, AKIHIKO, TANAKA, SHIGEKI, YOSHIDA, SATORU, ISHIKAWA, KOICHI, ONOUE, MASAAKI, ISHIBASHI, MAKOTO
Format Journal Article
LanguageEnglish
Published The Japanese Circulation Society 1973
Subjects
Goldblatt hypertensive dog
Nephrectomy
Renal artery reconstruction
Renal homotransplantation
Renin-Angiotensin activity
Renovascular hypertension
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Summary:Surgical indications on renovascular hypertension, especially on the patients in chronic stage with low plasma renin activity, have not been settled yet. To solve this problem, the Goldblatt's hypertensive dogs were subjected to successful renal homotransplantation or renal artery reconstruction during both the acute and the chronic phase. This experimental studies demonstrated clearly the antihypertensive effect of normal renal tissue to chronic renovascular hypertension due to other mechanism than renin-angiotensin system. Our clinical experiences and evaluation of collected operative cases in Japan supported this experimental results. Therefore, as far as operative techniques are exellent, renal artery reconstruction is more effective to normalize the blood pressure than nephrectomy, and preoperative measurement of plasma renin activity is very important to he selection of appropriate operation on the patients with renal artery stenosis and hypertension.
ISSN:0047-1828
1347-4839
DOI:10.1253/jcj.37.1049