Histological evaluation of rat mammary tumours after treatment with retinoic acid analogues — phytol, TTNPB and vitamin D3 analogue seocalcitol

The effects of retinoic acid analogue — phytol (precursor of retinoic X receptors ligand), TTNPB (retinoic acid receptor agonist) and seocalcitol (EB1089, analogue of vitamin D 3 ) in mammary tumours of Sprague-Dawley rats induced with 1-methyl-1-nitrosourea (MNU) were investigated. Treatment with p...

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Published inBiológia Vol. 66; no. 2; pp. 365 - 369
Main Authors Líška, Ján, Ondková, Slavomíra, Macejová, Dana, Brtko, Július
Format Journal Article
LanguageEnglish
Published Heidelberg SP Versita 01.04.2011
Versita
Subjects
1-methyl-1-nitrosourea
Biomedical and Life Sciences
Cell Biology
Life Sciences
mammary tumours
Microbiology
phytol
Plant Sciences
rats
Section Cellular and Molecular Biology
seocalcitol
TTNPB
Zoology
seocalcitol
phytol
1-methyl-1-nitrosourea
rats
mammary tumours
TTNPB
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Summary:The effects of retinoic acid analogue — phytol (precursor of retinoic X receptors ligand), TTNPB (retinoic acid receptor agonist) and seocalcitol (EB1089, analogue of vitamin D 3 ) in mammary tumours of Sprague-Dawley rats induced with 1-methyl-1-nitrosourea (MNU) were investigated. Treatment with phytol, TTNPB and seocalcitol may have some protective and therapeutical effects on malignant processes. Treatment with these components in combination of TTNPB and phytol or seocalcitol and phytol inhibited progression of MNU-induced tumours of the rat mammary gland, and also induced decrease of tumour burden and volume in comparison with treated control group. Treatment of rats with the above compounds had no effect on malignity and invasiveness of carcinomas.
ISSN:0006-3088
1336-9563
DOI:10.2478/s11756-011-0024-3