Cerebellar activation in opsoclonus: an fMRI study

It is controversial whether opsoclonus is a cerebellar or brainstem disorder. Two patients whose opsoclonus largely disappeared on eye closure underwent fMRI. A comparison of these two states revealed neither vermal nor brainstem activation but rather a bilateral activation in the deep cerebellar nu...

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Bibliographic Details
Published inNeurology Vol. 61; no. 3; p. 412
Main Authors Helmchen, C, Rambold, H, Sprenger, A, Erdmann, C, Binkofski, F
Format Journal Article
LanguageEnglish
Published United States 12.08.2003
Subjects
Adult
Aged
Cerebellar Nuclei - physiopathology
Cerebellum - diagnostic imaging
Cerebellum - physiopathology
Eye Movements - physiology
Female
Fixation, Ocular
Humans
Magnetic Resonance Imaging
Male
Ocular Motility Disorders - diagnosis
Ocular Motility Disorders - physiopathology
Reference Values
Tomography, X-Ray Computed
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Summary:It is controversial whether opsoclonus is a cerebellar or brainstem disorder. Two patients whose opsoclonus largely disappeared on eye closure underwent fMRI. A comparison of these two states revealed neither vermal nor brainstem activation but rather a bilateral activation in the deep cerebellar nuclei in excess of what the authors found in healthy subjects. The results support a crucial role of the fastigial nucleus in opsoclonus.
ISSN:1526-632X
DOI:10.1212/01.WNL.0000073271.66866.51