Effect of Curcuma xanthorrhiza Supplementation on Systemic Lupus Erythematosus Patients with Hypovitamin D Which Were Given Vitamin D 3 towards Disease Activity (SLEDAI), IL-6, and TGF- β 1 Serum

• Published in: International journal of rheumatology Vol. 2017; pp. 7687053 - 8
• Main Authors: Singgih Wahono, C, Diah Setyorini, Cameleia, Kalim, Handono, Nurdiana, Nurdiana, Handono, Kusworini
• Format: Journal Article
• Language: English
• Published: United States 2017
• ISSN: 1687-9260; 1687-9279
• DOI: 10.1155/2017/7687053

Curcumin contained in is an immunomodulator that has similar biological effect as vitamin D. Combination of curcumin and vitamin D is expected to work synergistically. To determine the effect of supplementation on vitamin D administration to SLEDAI, IL-6, and TGF- 1 serum in SLE patients with hypovitamin D. This was a double-blind RCT conducted in Saiful Anwar Hospital, Malang, in January 2016-March 2017. Subjects were SLE active (SLEDAI > 3) with levels of 25(OH)D3 ≤ 30 ng/ml and divided into two groups: those receiving cholecalciferol 3 × 400 IU and placebo 3 × 1 tablets (group I) and those receiving 3 × 400 IU cholecalciferol and 3 × 20 mg for 3 months (group II). SLEDAI, levels of vitamin D, IL-6, and TGF- 1 in serum were evaluated before and after the treatment. There were no significant differences in SLEDAI reduction, decreased serum levels of IL-6, and increased levels of TGF- 1 serum among groups after the treatment. Decreased levels of serum IL-6 have a positive correlation with SLEDAI reduction. supplementation on vitamin D had no effects on SLEDAI and serum levels of IL-6 and TGF- 1. This clinical trial is registered with NCT03155477.