Synthesis and transformations of 1-[2-(toluene-4-sulfonamido)ethyl]thiourea

Abstract Readily available 2-(toluene-4-sulfonylamino)ethylamine is a convenient starting material for a two-step synthesis of 1-[2-(toluene-4-sulfonamido)ethyl]thiourea ( 2 ). Heterocyclization of the thiourea moiety in 2 furnished a thiazole derivative 3 which was further functionalized into subst...

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Bibliographic Details
Published inHeterocyclic communications Vol. 19; no. 2; pp. 121 - 124
Main Authors Eliazyan, Karine, Hakobyan, Ruzanna, Pivazyan, Vergush, Ghazaryan, Emma, Yengoyan, Aleksandr
Format Journal Article
LanguageEnglish
Published Berlin Walter de Gruyter GmbH 01.04.2013
Subjects
Chemical synthesis
Organic chemistry
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Summary:Abstract Readily available 2-(toluene-4-sulfonylamino)ethylamine is a convenient starting material for a two-step synthesis of 1-[2-(toluene-4-sulfonamido)ethyl]thiourea ( 2 ). Heterocyclization of the thiourea moiety in 2 furnished a thiazole derivative 3 which was further functionalized into substituted thiazoles 4–6 . A series of 2-(thiazol-5-yl)-[1,3,4]oxadiazoles 8 , 10 and 2-(thiazol-5-yl)-[1,3,4]thiadiazoles 9 , 11 were obtained.
ISSN:0793-0283
2191-0197
DOI:10.1515/hc-2013-0005