Annulation of Eight- to Ten-Membered Oxaza Rings to the Benzo[b]thiophene System by Intramolecular Nucleophilic Displacement

Concise synthetic routes to 2H-benzo[b]thieno[3,2-b][1,5]oxazocin-6(3H)-one, and the new benzo[b]thieno[3,2-b][1,5]oxazonin-7(2H)-one and 2H-benzo[b]thieno[3,2-b][1,5]oxazecin-8(3H)-one systems, have been developed based on intramolecular nucleophilic displacement in the key ring forming step.

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Bibliographic Details
Published inAustralian journal of chemistry Vol. 67; no. 8-9; pp. 1217 - 1221
Main Authors Bremner, John B., Wu, Zemin
Format Journal Article
LanguageEnglish
Published COLLINGWOOD Csiro Publishing 01.01.2014
Subjects
Chemistry
Chemistry, Multidisciplinary
Physical Sciences
Science & Technology
DESIGN
HETEROCYCLES
REDUCTION
ACIDS
ESTERS
DERIVATIVES
NK1 ANTAGONISTS
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Summary:Concise synthetic routes to 2H-benzo[b]thieno[3,2-b][1,5]oxazocin-6(3H)-one, and the new benzo[b]thieno[3,2-b][1,5]oxazonin-7(2H)-one and 2H-benzo[b]thieno[3,2-b][1,5]oxazecin-8(3H)-one systems, have been developed based on intramolecular nucleophilic displacement in the key ring forming step.
ISSN:0004-9425
1445-0038
DOI:10.1071/CH14055