The Effects of MMP3 (rs679620) and VDR (rs731236) Gene Polymorphisms on Dental Caries: A Pilot Study
Caries formation is a process affected by various factors. Studies have shown that genetic factors also play a role in caries formation. The aim of our study is to examine the effects of matrix metalloproteinase ( (rs679620) and vitamin D receptor ( ) (rs731236) gene polymorphisms on caries formatio...
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Published in | European journal of dentistry |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
Published |
Germany
19.07.2024
|
Online Access | Get full text |
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Summary: | Caries formation is a process affected by various factors. Studies have shown that genetic factors also play a role in caries formation. The aim of our study is to examine the effects of matrix metalloproteinase (
(rs679620) and vitamin D receptor (
) (rs731236) gene polymorphisms on caries formation.
Following routine oral examinations in individuals aged between 20 and 44 years, the diagnosis was made according to the decayed, missing, and filled teeth (DMFT) index, and experimental group was defined as "high caries risk" (DMFT ≥ 14,
= 28), and the control group as "no caries" (DMFT = 0,
= 28). Plaque index and bleeding on probing were measured from participants with a detailed anamnesis. Periodontally healthy individuals with less than 10% bleeding on probing were included in the study (
= 56). After DNA isolation from blood samples taken from the participants, the genotyping of
(rs679620) and
(rs731236) gene polymorphisms were determined using the real-time polymerase chain reaction technique.
Data were analyzed with IBM SPSS V23.0. Data distribution was evaluated with Kolmogorov-Smirnov's test. Pearson's chi-square test was used to compare categorical data according to groups. The results were evaluated using a significance level of
< 0.05.
Regarding
and
gene polymorphisms, there was a statistically significant difference between the groups in terms of
(rs679620) (
< 0.001). There was no statistically significant difference between the
(rs731236) genotype distributions of the groups (
= 0.659).
Within the limits of this study,
rs679620 gene polymorphism may have an effect on caries formation. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 1305-7456 1305-7464 |
DOI: | 10.1055/s-0044-1787978 |