Strategy to Efficient Photodynamic Therapy for Antibacterium: Donor‐Acceptor Structure in Hydrogen‐Bonded Organic Framework

• Published in: Advanced materials (Weinheim) Vol. 36; no. 35; pp. e2406026 - n/a
• Main Authors: Zou, Ying, Liu, Hai‐Xiong, Cai, Lei, Li, Yu‐Hang, Hu, Jiang‐Shan, Liu, Chen, Liu, Tian‐Fu
• Format: Journal Article
• Language: English
• Published: Germany Wiley Subscription Services, Inc 01.08.2024
• Subjects: Atomic energy levels; Bonding; Covalent bonds; donor‐acceptor structure; Energy gap; Hydrogen; Hydrogen bonds; hydrogen‐bonded organic framework; Photodynamic therapy; singlet oxygen; photodynamic therapy singlet oxygen; hydrogen‐bonded organic framework; donor‐acceptor structure
• ISSN: 0935-9648; 1521-4095; 1521-4095
• DOI: 10.1002/adma.202406026

While the construction of a donor‐acceptor (D‐A) structure has gained great attention across various scientific disciplines, such structures are seldomly reported within the field of hydrogen‐bonded organic frameworks (HOFs). Herein, a D‐A based HOF is synthesized, where the adjacent D‐A pairs are connected by hydrogen bonds instead of the conventionally employed covalent bonds. This structural feature imparts material with a reduced energy gap between excited state and triplet state, thereby facilitating the intersystem crossing (ISC) and boosting the generation rate of single oxygen (quantum yield = 0.98). Consequently, the resulting material shows high performance for antimicrobial photodynamic therapy (PDT). The impact of D‐A moiety is evident when comparing this finding to a parallel study conducted on an isoreticular HOF without a D‐A structure. The study presented here provides in‐depth insights into the photophysical properties of D‐A pair in a hydrogen‐bonded network, opening a new avenue to the design of innovative materials for efficient PDT. A donor‐acceptor (D‐A) based hydrogen‐bonded organic framework (HOF) (PFC‐111) connected through hydrogen bonds instead of the conventionally employed covalent bonds shows a diminished △EST but large exciton binding energy. This distinctive structure endows PFC‐111 to exhibit excellent quantum yield of 1O2 generation via triplet‐triplet energy transfer (TTET) process, showing promising for antimicrobial photodynamic therapy (PDT).