Apoptotic Signal Pathways and Regulatory Mechanisms of Cancer Cells Induced by IL-24

The melanoma differentiation-associated gene-7（mda-7）,IL-24,has the specific functions that induce cancer cell apoptosis without doing harm to normal cells. We systematically review the apoptotic signal pathways and their regulatory mechanisms induced by Ad.IL-24 and IL-24 in diverse cancer cells. I...

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Published inWuhan University journal of natural sciences Vol. 21; no. 6; pp. 519 - 530
Main Authors Liu, Huilin, Chen, Jiaojiao, Jiang, Xingyan, Wang, Tao, Xie, Xiaoyuan, Hu, Hui, Yu, Fang, Wang, Xingzhi, Fan, Handong
Format Journal Article
LanguageEnglish
Published Wuhan Wuhan University 01.12.2016
Springer Nature B.V
Subjects
Apoptosis
Biomedical and Life Sciences
Cancer
Clusterin
Computer Science
Differentiation
Downstream effects
Effectors
Interleukin 24
JNK protein
Life Sciences
MAP kinase
Materials Science
Mda-7 protein
Melanoma
Mitochondria
Proteins
Regulatory mechanisms (biology)
Review
Signal transduction
Transduction
Tumor cells
Wnt protein
β-Catenin
apoptosis
IL-24
signal pathway
tumor
Q257
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Summary:The melanoma differentiation-associated gene-7（mda-7）,IL-24,has the specific functions that induce cancer cell apoptosis without doing harm to normal cells. We systematically review the apoptotic signal pathways and their regulatory mechanisms induced by Ad.IL-24 and IL-24 in diverse cancer cells. IL-24 can participate in varied signal transduction pathways,including JAK,p38 MAPK,Wnt/β-catenin,JNK,ER stress and mitochondria-associated signal pathways. And we review five proteins interacting with IL-24,including Bip/GRP78,S1 R,PKR,Beclin1 and soluble clusterin,which are relative to the tumor-specific effect of IL-24. It is speculated that ER stress,G-protein pathways and MAPK signal pathways may be the primary upstream effectors which activate the sequential downstream mediators resulting in apoptosis induced by IL-24 in tumor cells. Experimental results also show that IL-24 sensitizes cancer cells and indirectly promotes apoptosis rather than functions as a direct apoptosis inducer itself.
Bibliography:42-1405/N
apoptosis IL-24 signal pathway tumor
The melanoma differentiation-associated gene-7（mda-7）,IL-24,has the specific functions that induce cancer cell apoptosis without doing harm to normal cells. We systematically review the apoptotic signal pathways and their regulatory mechanisms induced by Ad.IL-24 and IL-24 in diverse cancer cells. IL-24 can participate in varied signal transduction pathways,including JAK,p38 MAPK,Wnt/β-catenin,JNK,ER stress and mitochondria-associated signal pathways. And we review five proteins interacting with IL-24,including Bip/GRP78,S1 R,PKR,Beclin1 and soluble clusterin,which are relative to the tumor-specific effect of IL-24. It is speculated that ER stress,G-protein pathways and MAPK signal pathways may be the primary upstream effectors which activate the sequential downstream mediators resulting in apoptosis induced by IL-24 in tumor cells. Experimental results also show that IL-24 sensitizes cancer cells and indirectly promotes apoptosis rather than functions as a direct apoptosis inducer itself.
ISSN:1007-1202
1993-4998
DOI:10.1007/s11859-016-1205-2