Comprehensive review of perioperative factors influencing ferroptosis

• Published in: Biomedicine & pharmacotherapy Vol. 179; p. 117375
• Main Authors: Fan, Cheng-Hui, Zeng, Xiao-Qin, Feng, Rui-Min, Yi, Hua-Wei, Xia, Rui
• Format: Journal Article
• Language: English
• Published: France Elsevier Masson SAS 01.10.2024; Elsevier
• Subjects: Anesthesia; Anesthetics - adverse effects; Animals; Blood Transfusion; Ferroptosis; Ferroptosis - drug effects; Ferroptosis - physiology; Humans; Hypothermia; Hypoxia; Perioperative Care - methods; Perioperative Period; Postoperative Complications - etiology; Postoperative Complications - prevention & control; Reperfusion Injury; Stress; Ferroptosis; Hypoxia; Anesthesia; Perioperative period; Stress
• ISSN: 0753-3322; 1950-6007; 1950-6007
• DOI: 10.1016/j.biopha.2024.117375

The perioperative period encompasses all phases of patient care from the decision to perform surgery until full recovery. Ferroptosis, a newly identified type of regulated cell death, influences a wide array of diseases, including those affecting the prognosis and regression of surgical patients, such as ischemia-reperfusion injury and perioperative cognitive dysfunction. This review systematically examines perioperative factors impacting ferroptosis such as surgical trauma-induced stress, tissue hypoxia, anesthetics, hypothermia, and blood transfusion. By analyzing their intrinsic relationships, we aim to improve intraoperative management, enhance perioperative safety, prevent complications, and support high-quality postoperative recovery, ultimately improving patient outcomes. [Display omitted] •Stress, hypoxia and anesthesia affect ferroptosis in surgery.•Classical regulatory mechanisms of ferroptosis.•Optimizing perioperative management reduces ferroptosis.•Modulating ferroptosis improves surgical outcomes.