In vivo inactivation of transglutaminase during the acute acrylamide toxic syndrome in the rat

The activity of liver and brain transglutaminase is rapidly lost following i.p. injection of acrylamide (50-200 mg/kg). Other enzymes investigated were not modified by the treatment, with the exception of brain enolase.

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Bibliographic Details
Published inExperientia Vol. 46; no. 3; p. 278
Main Authors Bergamini, C M, Signorini, M
Format Journal Article
LanguageEnglish
Published Switzerland 15.03.1990
Subjects
Acrylamides - administration & dosage
Acrylamides - toxicity
Animals
Brain - drug effects
Brain - enzymology
Depression, Chemical
Dose-Response Relationship, Drug
Liver - drug effects
Liver - enzymology
Male
Rats
Rats, Inbred Strains
Transglutaminases - antagonists & inhibitors
Transglutaminases - metabolism
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Summary:The activity of liver and brain transglutaminase is rapidly lost following i.p. injection of acrylamide (50-200 mg/kg). Other enzymes investigated were not modified by the treatment, with the exception of brain enolase.
ISSN:0014-4754
DOI:10.1007/BF01951765