Dolastatins .23. Stereospecific synthesis of dolaisoleuine

The remarkable antineoplastic peptide dolastatin 10, isolated from the opisthobranchia mollusc Dolabella auricularia, is currently in clinical development and further improvements in its total synthesis have been undertaken. Major effort has been directed at devising more stereoselective routes to t...

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Bibliographic Details
Published inJournal of the Chemical Society, Perkin Transactions 1 no. 8; pp. 853 - 858
Main Authors Pettit, GR, Burkett, DD, Williams, MD
Format Journal Article
LanguageEnglish
Published CAMBRIDGE Royal Soc Chemistry 21.04.1996
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
ACYCLIC STEREOSELECTION
ASYMMETRIC ALDOL REACTIONS
LEUKEMIA-CELL LINES
GROWTH
TRANSITION-STATE GEOMETRY
ANTINEOPLASTIC AGENTS
ENOLATE
CONDENSATION
TUBULIN
REVERSAL
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Summary:The remarkable antineoplastic peptide dolastatin 10, isolated from the opisthobranchia mollusc Dolabella auricularia, is currently in clinical development and further improvements in its total synthesis have been undertaken. Major effort has been directed at devising more stereoselective routes to the dolastatin 10 amino acid units dolaisoleuine 2 and dolaproine 3, each bearing three chiral centres. We report herein highly stereoselective routes to both natural (3R,4S,5S)-dolaisoleuine 2 and its 3S,4S,5S-isomer 14 (Z replaces H) using an asymmetric aldol methodology. Key reaction steps are condensation of chiral alpha-(methylsulfanyl)acetyloxazolidinone 4d with (S)-N-Z-N-Me-isoleucinal 6 using dibutylboron triflate followed by reductive desulfurization, O-methylation and cleavage of the oxazolidinone auxiliary to complete a simple route to N-benzyloxycarbonyldolaisoleuine 10. By substituting chiral oxazolidinone 54 for 4d the 3S-isomer of N-benzyloxycarbonyldolaisoleuine 14 was selectively obtained.
ISSN:0300-922X
1364-5463
DOI:10.1039/p19960000853