Serum LDL cholesterol, the LDL/HDL cholesterol ratio and liver microsomal enzyme induction evaluated by antipyrine kinetics

• Published in: Scandinavian journal of clinical and laboratory investigation Vol. 43; no. 8; p. 671
• Main Authors: Luoma, P V, Sotaniemi, E A, Arranto, A J
• Format: Journal Article
• Language: English
• Published: England 01.12.1983
• Subjects: Adult; Anticonvulsants - pharmacology; Antipyrine - metabolism; Cholesterol - blood; Cholesterol, HDL; Cholesterol, LDL; Coronary Disease - etiology; Enzyme Induction - drug effects; Female; Humans; Kinetics; Lipoproteins, HDL - blood; Lipoproteins, LDL - blood; Male; Microsomes, Liver - enzymology; Middle Aged; Risk
• ISSN: 0036-5513
• DOI: 10.3109/00365518309168848

The association of serum LDL and HDL cholesterol with hepatic microsomal enzyme induction, assessed by plasma antipyrine kinetics was investigated in 30 epileptics. Patients on enzyme-inducing anticonvulsants had reduced LDL/HDL cholesterol ratios and elevated HDL cholesterol concentrations and HDL/total cholesterol ratios, indicating a cholesterol transfer from LDL to HDL. Strong hepatic microsomal enzyme induction was associated with reduced LDL cholesterol. The LDL/HDL cholesterol ratio was negatively proportional and the HDL/total cholesterol ratio positively proportional to the antipyrine clearance rate. Epileptics, particularly those with a high antipyrine clearance, had a cholesterol distribution pattern characteristic of a low probability of developing coronary atherosclerosis. The results support the view that hepatic microsomal enzyme induction favourably alters the cholesterol distribution in the body.