Green synthesis of magnesium oxide nanoparticles using the extract of Falcaria vulgaris to enhance the healing of burn wounds

• Published in: Journal of drug targeting Vol. 33; no. 5; p. 761
• Main Authors: Khazaei, Mozafar, Meskaraf-Asadabadi, Mohammadali, Khazaei, Fatemeh, Kadivarian, Sepide, Ghanbari, Elham
• Format: Journal Article
• Language: English
• Published: England 01.06.2025
• Subjects: Animals; Anti-Bacterial Agents - administration & dosage; Anti-Bacterial Agents - pharmacology; Burns - drug therapy; Burns - pathology; Fibroblasts - drug effects; Green Chemistry Technology - methods; Humans; Magnesium Oxide - administration & dosage; Magnesium Oxide - chemistry; Magnesium Oxide - pharmacology; Male; Nanoparticles - chemistry; Plant Extracts - chemistry; Plant Extracts - pharmacology; Rats; Rats, Wistar; Staphylococcus aureus - drug effects; Wound Healing - drug effects; skin; burn; Wound healing; nanoparticles; Falcaria vulgaris; magnesium oxide
• ISSN: 1029-2330
• DOI: 10.1080/1061186X.2024.2445744

Treating burn lesions has always been challenging because any product should be cheap, accessible, and have anti-bacterial commodities and tissue regeneration properties. The green synthesis of magnesium oxide nanoparticles (GS-MgONPs) can create an optimal prospect that is safe with low toxicity in biological tissue and better safety for application while including the antibacterial effect. This recent study aimed to evaluate the effectiveness of burn wound treatment using GS-MgONPs in rats. GS-MgONPs were synthesised for the first time using a Falcaria vulgaris extract (FVE) and characterised. Thirty male Wistar rats were divided into five groups: An untreated group, conventional product treated group, GS-MgONPs (1 wt%), GS-MgONPs (3 wt%) and 5. FVE (1 wt%). Treatments commenced immediately following burn induction and were administered daily for a duration of 21 d. GS-MgONPs showed a spherical morphology with a diameter of less than 100 nm. The NPs (1% and 3 wt%) and FVE demonstrated significant growth inhibition against Staphylococcus aureus while showing no cytotoxic effects on human fibroblast cells. The proposed subjects treated with 1 wt% and 3 wt% GS-MgONPs were able to significantly increase the rate of wound closure (p < 0.05). Histological observations revealed that collagen formation and epithelial regeneration were more pronounced in the groups receiving 1 wt% and 3 wt% MgONPs. These results indicate that GS-MgONPs effectively enhance the regeneration process.