Genetic variants of folate metabolism and the risk of multiple sclerosis

• Published in: Neurological research (New York) Vol. 46; no. 6; p. 544
• Main Authors: Aşcı, Ali Erkan, Orhan, Gürdal, Karahalil, Bensu
• Format: Journal Article
• Language: English
• Published: England 02.06.2024
• Subjects: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase - genetics; Adult; Cysteine - genetics; Female; Ferredoxin-NADP Reductase - genetics; Folic Acid - blood; Folic Acid - metabolism; Genetic Predisposition to Disease - genetics; Homocysteine - blood; Homocysteine - metabolism; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2) - genetics; Middle Aged; Multiple Sclerosis - blood; Multiple Sclerosis - genetics; Vitamin B 12 - blood; Folate metabolism; MTRR; cysteine; MTHFR; gene polymorphism; MTR; VitB12; homocystein
• ISSN: 1743-1328
• DOI: 10.1080/01616412.2024.2337519

Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS) of unknown cause. Alterations in one-carbon metabolism have impact in the pathophysiology by genetic susceptibility to MS and increased the risk of MS. The aim of this study was to investigate the contribution of the gene polymorphism on Methylenetetrahydrofolate Reductase ( ), Methionine Synthase Reductase ( ), Methionine Synthase ) enzymes and of the essential factors (homocysteine, ; cysteine, ; and vitamin B12, ) in folate metabolism. Eligible MS patients (  = 147) and health controls (  = 127) were participated. The gene polymorphisms were analyzed by Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP) and the levels of plasma and tB12 were measured by Enzyme Linked Immunuabsorbent Assay (ELISA). Our results showed that the levels of and were lower and the levels of were higher in MS compared to controls. The observation of high values in all 3 gene polymorphisms suggests that the transsulfiration pathway of is directed towards formation since the methionine synthesis pathway does not work. We could not find any association with all gene polymorphisms with the risk of MS. The allele of and allele of are risk factors for serum level on MS. As for , serum vitB12 was observed in MS patients with allele.