Systemic meta-analysis: apigenin's effects on lung inflammation and oxidative stress

• Published in: The Journal of asthma Vol. 61; no. 4; p. 271
• Main Authors: Wang, Fangfang, Xiao, Lianghua, Zhang, Huahua, Wang, Yan, Zhong, Lin, Feng, Xinwei, Liu, Jianping, Gong, Xiangwen
• Format: Journal Article
• Language: English
• Published: England 02.04.2024
• Subjects: Acute Lung Injury - drug therapy; Animals; Anti-Inflammatory Agents - pharmacology; Anti-Inflammatory Agents - therapeutic use; Antioxidants - pharmacology; Antioxidants - therapeutic use; Apigenin - pharmacology; Apigenin - therapeutic use; Disease Models, Animal; Oxidative Stress - drug effects; Pneumonia - drug therapy; Rats; anti-inflammatory; apigenin; Acute lung injury; flavonoids
• ISSN: 1532-4303
• DOI: 10.1080/02770903.2023.2272804

This study aimed to investigate the potential anti-inflammatory and antioxidant effects of apigenin in rats with acute lung injury (ALI). We also examined changes in levels of inflammatory and antioxidant factors after apigenin treatment in a rat model of ALI. We searched several databases, including PubMed, Scopus, EMBASE, Web of Science, ProQuest, and GoogleScholar, to retrieve relevant articles for our systematic review and meta-analysis.Five studies with 226 rat models of ALI were included in this study. We investigated inflammatory factors and oxidative stress with the corresponding 95% confidence interval in three groups: 1. Group1 (control vs. ALI), 2. Group2 (ALI vs. apigenin10), and 3. Group3 (ALI vs. apigenin20). Estimating the correlation and 95% confidence intervals for the inflammatory agents and oxidative stress in the intervention group (ALI), compared with that in the control group, respectively (correlation: 0.194; 95% confidence intervals, 0.101-0.282, value = .001, z-value= 4.08) and (correlation: 0.099; 95% confidence intervals, 0.016-0.182, value = .020, z value= 2.325). Estimating the correlation and 95% confidence intervals for the inflammatory agents and oxidative stress in the intervention group (apigenin 10 mg/kg), compared with that in the control group (ALI), respectively (correlation: 0.476; 95% confidence intervals, 0.391-0.553,  value = .001, z-value= 9.678) and (correlation: 0.415; 95% confidence intervals, 0.313-0.508, value= .001, z-value= 7.349). Apigenin may have potential anti-inflammatory and antioxidant effects in rat models of ALI. However, the efficacy of apigenin as a therapeutic strategy requires further investigation through prospective controlled randomized trials.