Propranolol in the treatment of acute myocardial infarction. Effect on myocardial oxygenation and hemodynamics

• Published in: Circulation (New York, N.Y.) Vol. 49; no. 6; pp. 1078 - 1087
• Main Authors: Mueller, H S, Ayres, S M, Religa, A, Evans, R G
• Format: Journal Article
• Language: English
• Published: United States 01.06.1974
• Subjects: Acute Disease; Adult; Aged; Blood Pressure - drug effects; Cardiac Catheterization; Cardiac Output - drug effects; Clinical Trials as Topic; Coronary Circulation - drug effects; Elasticity; Female; Glucose - metabolism; Heart Rate - drug effects; Humans; Lactates - metabolism; Lidocaine - therapeutic use; Male; Meperidine - therapeutic use; Middle Aged; Morphine - therapeutic use; Myocardial Infarction - drug therapy; Myocardium - metabolism; Oxygen Consumption - drug effects; Propranolol - therapeutic use; Pyruvates - metabolism; Vascular Resistance - drug effects
• ISSN: 0009-7322; 1524-4539
• DOI: 10.1161/01.CIR.49.6.1078

Improvement of myocardial oxygenation is a major goal in the treatment of ischemic heart disease. Propranolol, 0.1 mg/kg intravenously, was administered to 20 patients in the acute state of myocardial infarction without clinical evidence of left ventricular failure. The most important hemodynamic response was a substantial decrease in myocardial contractility. This was reflected by a fall i cardiac index (average of 0.6 L/min/M 2 , P < 0.001) and of arterial mean pressure (average of 16 mm Hg, P < 0.001) with little change in systemic vascular resistance. Decrease in cardiac index was due mainly to decrease in stroke volume. Heart rate, not strikingly increased at the control state in the majority of patients, decreased an average of 7 beats/min ( P < 0.001). Pulmonary wedge pressure rose an average of 2 mm Hg ( P < 0.05). It remained unchanged or decreased in three patients. These varying but small changes in wedge pressure in the presence of decreased contractility may be related to improved left ventricular compliance, produced by propranolol. Propranolol markedly improved myocardial metabolism. Arterial - coronary sinus oxygen difference decreased an average of 0.72 ml/100 ml ( P < 0.001); coronary sinus oxygen tension increased an average of 2 mm Hg. Myocardial lactate production shifted to extraction (average of -8% to 14%) or the rate of lactate extraction increased (average of 20% to 29%). Coronary blood flow decreased an average of 13 ml/100 g/min ( P < 0.001). Both decrease in mean aortic pressure and decrease in myocardial oxygen requirements probably contributed to the fall in coronary blood flow. The finding, that myocardial metabolism improved, suggests that reduction in myocardial oxygen demand outweighed the decrease in coronary blood flow. None of the 20 patients developed left ventricular failure or other complications related to beta-adrenergic blockade. Severe chest pain, unresponsive to conventional therapy in four patients, was relieved by propranolol. These findings demonstrate that acutely administered propranolol improves myocardial oxygenation in patients with uncomplicated acute infarction without endangering perfusion of other vital organs.