Synthesis, Structure, and Hemorheological Activity of Pentasubstituted Cyclohexanol

The intramolecular condensation of chalcone (benzylideneacetophenone) in a DMSO solution in the presence of KOH gave (4-hydroxy-2,4,6-triphenylcyclohexane-1,3-diyl)bis(phenylmethanone). Structure of the synthesized derivative was proved by 1 H, 13 C NMR spectroscopy, mass spectrometry and X-ray diff...

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Bibliographic Details
Published inRussian journal of general chemistry Vol. 91; no. 12; pp. 2462 - 2468
Main Authors Palamarchuk, I. V., Shulgau, Z. T., Sergazy, Sh. D., Zhulikeeva, A. M., Gatilov, Yu. V., Kulakov, I. V.
Format Journal Article
LanguageEnglish
Published Moscow Pleiades Publishing 01.12.2021
Springer
Subjects
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Cyclohexanol
Nuclear magnetic resonance spectroscopy
chalcone
cyclohexanol derivative
intramolecular cyclization
Michael reaction
X-ray diffraction analysis
hemorheological activity
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Summary:The intramolecular condensation of chalcone (benzylideneacetophenone) in a DMSO solution in the presence of KOH gave (4-hydroxy-2,4,6-triphenylcyclohexane-1,3-diyl)bis(phenylmethanone). Structure of the synthesized derivative was proved by 1 H, 13 C NMR spectroscopy, mass spectrometry and X-ray diffraction analysis. The obtained cyclohexanol derivative shows hemorheological activity: it is able to inhibit the growth of the viscosity of whole blood during the formation of the syndrome of increased blood viscosity in vitro .
ISSN:1070-3632
1608-3350
DOI:10.1134/S107036322112015X