Single-dose ornidazole versus seven-day metronidazole therapy of giardiasis in Kibbutzim children in Israel

The efficacy of single-dose ornidazole versus seven days metronidazole in the treatment of giardiasis was tested in a randomized study of 75 Kibbutzim children in Israel. All the children treated were clinically cured, and the parasites disappeared from stool examinations after the first follow-up....

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Published inEuropean journal of clinical microbiology & infectious diseases Vol. 10; no. 11; p. 963
Main Authors Oren, B, Schgurensky, E, Ephros, M, Tamir, I, Raz, R
Format Journal Article
LanguageEnglish
Published Germany 01.11.1991
Subjects
Animals
Child
Child, Preschool
Drug Administration Schedule
Female
Giardia lamblia - isolation & purification
Giardiasis - drug therapy
Humans
Infant
Israel
Male
Metronidazole - administration & dosage
Metronidazole - therapeutic use
Ornidazole - administration & dosage
Ornidazole - therapeutic use
Israel
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Summary:The efficacy of single-dose ornidazole versus seven days metronidazole in the treatment of giardiasis was tested in a randomized study of 75 Kibbutzim children in Israel. All the children treated were clinically cured, and the parasites disappeared from stool examinations after the first follow-up. By the end of the study (21 days after the beginning of treatment), all the patients remained free of symptoms, but cysts of Giardia lamblia were found in the stools of three children from the ornidazole group (p = 0.24). The possibility of treating Giardia lamblia with ornidazole in a single dose, with results similar to those obtained with a seven-day course of metronidazole, makes this drug a good alternative in the treatment of Giardia lamblia in children, especially if compliance is not assured.
ISSN:0934-9723
1435-4373
DOI:10.1007/BF02005454