SCH 23390 blocks D-1 and D-2 dopamine receptors in rat neostriatum in vitro
The agonistic and antagonistic effects of the new compound SCH 23390 were tested in functional model systems for the D-1 dopamine receptor and for the D-2 dopamine receptor in vitro. In superfused rat neostriatal slices the increase in the efflux of cyclic AMP was used as a parameter for D-1 recepto...
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Published in | Naunyn-Schmiedeberg's archives of pharmacology Vol. 327; no. 2; p. 180 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
Germany
01.09.1984
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Subjects | |
Online Access | Get more information |
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Summary: | The agonistic and antagonistic effects of the new compound SCH 23390 were tested in functional model systems for the D-1 dopamine receptor and for the D-2 dopamine receptor in vitro. In superfused rat neostriatal slices the increase in the efflux of cyclic AMP was used as a parameter for D-1 receptor stimulation. D-2 receptor stimulation was measured as the decrease in the K+-evoked release of [3H]-acetylcholine. SCH 23390 had no agonistic activity in these two models. SCH 23390 was a potent antagonist of the stimulating effect of dopamine in the D-1 receptor model (apparent pA2 = 7.28). SCH 23390 also antagonized the effect of the D-2 receptor agonist LY 141865 in the D-2 receptor model (apparent pA2 = 6.34). This D-2 receptor antagonism proved to be of a competitive nature. |
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ISSN: | 0028-1298 |
DOI: | 10.1007/BF00500914 |