Recurrent Second Trimester Fetal Demise Caused by Hypercoiled Umbilical Cords

Umbilical cord flow impairment accounts for a majority of fetal vascular malperfusion (FVM). Hypercoiled umbilical cords are one cause of impaired fetal blood flow that may, in severe cases, result in intrauterine fetal demise (IUFD). Although the factors involved in umbilical cord patterning are in...

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Bibliographic Details
Published inFetal and pediatric pathology Vol. 42; no. 3; pp. 492 - 497
Main Authors Slack, Jonathan C, Boyd, Theonia K, Carreon, Chrystalle Katte
Format Journal Article
LanguageEnglish
Published England 01.06.2023
Subjects
Female
Fetal Death - etiology
Fetus
Humans
Pregnancy
Pregnancy Trimester, Second
Stillbirth
Umbilical Cord
recurrent miscarriage
fetal vascular malperfusion
Hypercoiled umbilical cord
intrauterine fetal demise
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Summary:Umbilical cord flow impairment accounts for a majority of fetal vascular malperfusion (FVM). Hypercoiled umbilical cords are one cause of impaired fetal blood flow that may, in severe cases, result in intrauterine fetal demise (IUFD). Although the factors involved in umbilical cord patterning are incompletely understood, a limited number of reports have described recurrent intra-familial hypercoiling leading to death in the second trimester, suggesting a subset may have a genetic etiology. Herein, we report two additional cases of recurrent second trimester IUFD secondary to FVM due to umbilical cord hypercoiling and briefly discuss all published cases. Our cases add to a small, but growing, body of literature that suggests a genetic etiology to a subset of hypercoiled umbilical cords.
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ISSN:1551-3815
1551-3823
DOI:10.1080/15513815.2022.2142490