Effect of dipyridamole and adenosine monophosphate on cell proliferation in the hemopoietic tissue of normal and gamma-irradiated mice

Combined treatment with dipyridamole and adenosine monophosphate enhances cell proliferation in the hemopoietic tissue of normal and gamma-irradiated mice. This effect can be explained by the elevation of extracellular adenosine, and the receptor-mediated activation of the cell adenylate cyclase sys...

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Bibliographic Details
Published inExperientia Vol. 48; no. 3; p. 253
Main Authors Pospísil, M, Hofer, M, Netíková, J, Viklická, S, Pipalová, I, Bartonícková, A
Format Journal Article
LanguageEnglish
Published Switzerland 15.03.1992
Subjects
Adenosine - physiology
Adenosine Monophosphate
Animals
Blood Cells - cytology
Bone Marrow Cells
Cell Division - drug effects
Cell Division - physiology
Cell Division - radiation effects
Dipyridamole
Gamma Rays
Male
Mice
Mice, Inbred C57BL
Mice, Inbred CBA
Spleen - cytology
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Summary:Combined treatment with dipyridamole and adenosine monophosphate enhances cell proliferation in the hemopoietic tissue of normal and gamma-irradiated mice. This effect can be explained by the elevation of extracellular adenosine, and the receptor-mediated activation of the cell adenylate cyclase system.
ISSN:0014-4754
DOI:10.1007/BF01930468