Assembled growth of 3D Fe3O4@Au nanoparticles for efficient photothermal ablation and SERS detection of microorganisms

The development of a single agent with multifunctionality for the rapid detection and inhibition of the spread of pathogenic microorganisms is of great importance for environmental hygiene as well as water and food safety. For this purpose, we integrate plasmonic nano-Au, near-infrared (NIR)-activat...

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Published inJournal of materials chemistry. B, Materials for biology and medicine Vol. 6; no. 36; pp. 5689 - 5697
Main Authors Wei-En, Hong, I-Ling, Hsu, Huang, Szu-Yung, Chien-Wei, Lee, Ko, Han, Pei-Jane Tsai, Dar-Bin Shieh, Chih-Chia Huang
Format Journal Article
LanguageEnglish
Published Cambridge Royal Society of Chemistry 28.09.2018
Subjects
Ablation
Anaerobic bacteria
Bacteria
Dopamine
E coli
Environmental hygiene
Food safety
Gold
Hygiene
Iron oxides
Leukocytes
Magnetic properties
Magnetism
Methylene blue
Microorganisms
Nanoparticles
Optical properties
Photothermal conversion
Raman spectra
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Summary:The development of a single agent with multifunctionality for the rapid detection and inhibition of the spread of pathogenic microorganisms is of great importance for environmental hygiene as well as water and food safety. For this purpose, we integrate plasmonic nano-Au, near-infrared (NIR)-activated Fe3O4 nanoclusters, and NIR-absorbing polydopamine to form a leukocyte-like Fe3O4@Au nanostructure to treat microorganisms. Through high-temperature reduction of HAuCl4 with l-dopamine, Au atoms are spontaneously generated along with Fe3O4 nanoclusters via a site-selected atom deposition process between the Au(111) and Fe3O4(222) lattice planes. Combining the magnetic properties of Fe3O4 and the optical functionality of gold nanoparticles, the Fe3O4@Au nanohybrid exhibits effective photothermal conversion and magnetism-guided aggregation to improve the molecular surface-enhanced Raman scattering (SERS) signal, achieving a limit of detection on the micromolar to nanomolar level for methylene blue (MB) and 4-aminothiophenol (4-ATP). After magnetism-assisted adsorption, we adopt Escherichia coli (E. coli) as a model analyte and demonstrate label-free SERS sensing of bacterial cell molecular structures based on optical fingerprints and recyclable photothermal ablation of bacterial pathogens (Gram-positive, Gram-negative, and anaerobic bacteria).
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ISSN:2050-750X
2050-7518
DOI:10.1039/c8tb00599k