ALSUntangled # 69: astaxanthin

ALSUntangled reviews alternative and off-label treatments for people living with amyotrophic lateral sclerosis (PALS). Here we review astaxanthin which has plausible mechanisms for slowing ALS progression including antioxidant, anti-inflammatory, and anti-apoptotic effects. While there are no ALS-sp...

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Published inAmyotrophic lateral sclerosis and frontotemporal degeneration Vol. 24; no. 5-6; pp. 553 - 557
Main Authors Fullam, Timothy, Armon, Carmel, Barkhaus, Paul, Barnes, Benjamin, Beauchamp, Morgan, Benatar, Michael, Bertorini, Tulio, Bowser, Robert, Bromberg, Mark, Mascias Cadavid, Javier, Carter, Gregory T, Dimachkie, Mazen, Ennist, Dave, Feldman, Eva L, Heiman-Patterson, Terry, Jhooty, Sartaj, Lund, Isaac, Mcdermott, Christopher, Pattee, Gary, Ratner, Dylan, Wicks, Paul, Bedlack, Richard
Format Journal Article
LanguageEnglish
Published England 01.08.2023
Subjects
Amyotrophic Lateral Sclerosis - drug therapy
Complementary Therapies
Humans
neurodegeneration
Amyotrophic lateral sclerosis
alternative therapy
oxidative stress
astaxanthin
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Summary:ALSUntangled reviews alternative and off-label treatments for people living with amyotrophic lateral sclerosis (PALS). Here we review astaxanthin which has plausible mechanisms for slowing ALS progression including antioxidant, anti-inflammatory, and anti-apoptotic effects. While there are no ALS-specific pre-clinical studies, one verified "ALS reversal" occurred in a person using a combination of alternative therapies which included astaxanthin. There have been no trials of astaxanthin in people living with ALS. Natural astaxanthin appears to be safe and inexpensive. Based on the above information, we support further pre-clinical and/or clinical trials of astaxanthin in disease models and PALS, respectively, to further elucidate efficacy.
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ISSN:2167-8421
2167-9223
DOI:10.1080/21678421.2023.2171302