Antiproliferative Compounds from Cleistanthus boivinianus from the Madagascar Dry Forest1

• Published in: Journal of natural products (Washington, D.C.) Vol. 78; no. 7; pp. 1543 - 1547
• Main Authors: Liu, Yixi, Young, Kelly, Rakotondraibe, L. Harinantenaina, Brodie, Peggy J., Wiley, Jessica D., Cassera, Maria B., Callmander, Martin W., Rakotondrajaona, R., Rakotobe, Etienne, Rasamison, Vincent E., TenDyke, Karen, Shen, Yongchun, Kingston, David G. I.
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 19.06.2015; American Chemical Society and American Society of Pharmacognosy
• ISSN: 0163-3864; 1520-6025
• DOI: 10.1021/np501020m

The two new lignans 3α- O -(β- d -glucopyranosyl)desoxypodophyllotoxin ( 1 ) and 4- O -(β- d -glucopyranosyl)dehydropodophyllotoxin ( 2 ) were isolated from Cleistanthus boivinianus , together with the known lignans deoxypicropodophyllotoxin ( 3 ), (±)-β-apopicropodophyllin ( 4 ), (−)-desoxypodophyllotoxin ( 5 ), (−)-yatein ( 6 ), and β-peltatin-5- O -β- d -glucopyranoside ( 7 ). The structures of all compounds were characterized by spectroscopic techniques. Compounds 1 , 4 , and 5 showed potent antiproliferative activities against the A2780 ovarian cancer cell line, with IC 50 values of 33.0 ± 3.6, 63.1 ± 6.7, and 230 ± 1 nM, respectively. Compounds 2 and 7 showed only modest A2780 activities, with IC 50 values of 2.1 ± 0.3 and 4.9 ± 0.1 μM, respectively, while compounds 3 and 6 had IC 50 values of >10 μM. Compound 1 also had potent antiproliferative activity against the HCT-116 human colon carcinoma cell line, with an IC 50 value of 20.5 nM, and compound 4 exhibited modest antiproliferative activity against the A2058 human caucasian metastatic melanoma and MES-SA human uterine sarcoma cell lines, with IC 50 values of 4.6 and 4.0 μM, respectively.