The Production of a Hyperimmune Serum for Infectious Abortion in Mares

A hyperimmune serum for infectious abortion in mares can be produced that has marked bacteriolytic properties in vitro. This serum protects rabbits from the lethal dose of the organism. In one instance it protected from 5 times the lethal dose. The serum lengthened the time for abortion in one guine...

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Bibliographic Details
Published inThe Journal of infectious diseases Vol. 18; no. 4; pp. 397 - 401
Main Authors Good, Edwin S., Smith, Wallace V.
Format Journal Article
LanguageEnglish
Published The University of Chicago Press 01.04.1916
Memorial Institute for Infectious Diseases
Subjects
Abortion
Antiserum
Bacillus
Blood
Horses
Immunity
Infections
Infectious diseases
Inoculation
Lethal dose
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Summary:A hyperimmune serum for infectious abortion in mares can be produced that has marked bacteriolytic properties in vitro. This serum protects rabbits from the lethal dose of the organism. In one instance it protected from 5 times the lethal dose. The serum lengthened the time for abortion in one guinea-pig 12 days. The serum did not protect a mare from an artificial infection. The amount of the organism given, inoculated directly into the blood, was vastly more than could be gotten in a natural infection. The serum may prove of value in a stud where the infection is known to exist.
Bibliography:ark:/67375/HXZ-V8JRJ84R-G
istex:F315F7D313092F24FEAB56EB9FD613061D84E200
ISSN:0022-1899
1537-6613
DOI:10.1093/infdis/18.4.397