PROGRESSIVE MULTIFOCAL LEUKOENCEPHALOPATHY ASSOCIATED TO MULTIPLE SCLEROSIS THERAPIES: REVIEW OF THE LITERATURE

Progressive multifocal leukoencephalopathy (PML) is an opportunistic infection associated with the reactivation of the JC virus, causing a severe demyelination within the central nervous system in patients with immunosuppression caused by disease or secondary to use of drugs. Several therapies used...

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Bibliographic Details
Published inRomanian journal of neurology Vol. 14; no. 4; pp. 205 - 213
Main Authors Vladila, Ana-Maria, Mitrea, Dan-Andrei, Nica, Sanda Maria, Buraga, Ioan
Format Journal Article
LanguageEnglish
Published Amaltea Medical Publishing House 31.12.2015
Subjects
alemtuzamab
cerebral mri demyelinating lesion
dimethyl fumarate
fingolimod
jc virus
mirtazapine
multiple sclerosis
natalizumab
pcr
plasma exchange
pml
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Summary:Progressive multifocal leukoencephalopathy (PML) is an opportunistic infection associated with the reactivation of the JC virus, causing a severe demyelination within the central nervous system in patients with immunosuppression caused by disease or secondary to use of drugs. Several therapies used in the treatment of MS have reported cases of associated PML, most cases being related to Natalizumab treatment. In this article we review specific MS medication with a reported risk for PML, and also revise PML epidemiology, pathogenesis, treatment and available approaches on therapy in patients at high risk for developing this infection.
ISSN:1843-8148
2069-6094
DOI:10.37897/RJN.2015.4.4