Patient-Derived Bladder Cancer Xenografts

Patient-derived xenograft (PDX ) tumors are models developed by direct transplant of human tumors into immune-compromised hosts such as nude mice. These models retain the histological and genetic characteristics of the primary tumor and are considered a valuable platform for translational cancer res...

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Published inMethods in molecular biology (Clifton, N.J.) Vol. 1655; p. 169
Main Authors Bernardo, Carina, Santos, Lúcio Lara
Format Journal Article
LanguageEnglish
Published United States 2018
Subjects
Animals
Antineoplastic Agents - pharmacology
Disease Models, Animal
Drug Evaluation, Preclinical
Drug Screening Assays, Antitumor
Heterografts
Humans
Male
Mice
Urinary Bladder Neoplasms - drug therapy
Urinary Bladder Neoplasms - pathology
Xenograft Model Antitumor Assays
In vivo
Tumorgraft
Animal models
Xenograft
Bladder cancer
Drug testing
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Abstract Patient-derived xenograft (PDX ) tumors are models developed by direct transplant of human tumors into immune-compromised hosts such as nude mice. These models retain the histological and genetic characteristics of the primary tumor and are considered a valuable platform for translational cancer research. This chapter describes the methodology to establish and propagate bladder cancer PDX model.
AbstractList Patient-derived xenograft (PDX ) tumors are models developed by direct transplant of human tumors into immune-compromised hosts such as nude mice. These models retain the histological and genetic characteristics of the primary tumor and are considered a valuable platform for translational cancer research. This chapter describes the methodology to establish and propagate bladder cancer PDX model.
Author Santos, Lúcio Lara
Bernardo, Carina
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  givenname: Carina
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  organization: Institute for Biomedicine (IBiMED), University of Aveiro, Porto, Portugal. carinadbernardo@gmail.com
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  givenname: Lúcio Lara
  surname: Santos
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  organization: Department of Surgical Oncology, Portuguese Oncology Institute-Porto (IPO-Porto), Porto, Portugal
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CitedBy_id crossref_primary_10_1016_j_biopha_2022_114154
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Keywords In vivo
Tumorgraft
Animal models
Xenograft
Bladder cancer
Drug testing
Language English
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Snippet Patient-derived xenograft (PDX ) tumors are models developed by direct transplant of human tumors into immune-compromised hosts such as nude mice. These models...
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StartPage 169
SubjectTerms Animals
Antineoplastic Agents - pharmacology
Disease Models, Animal
Drug Evaluation, Preclinical
Drug Screening Assays, Antitumor
Heterografts
Humans
Male
Mice
Urinary Bladder Neoplasms - drug therapy
Urinary Bladder Neoplasms - pathology
Xenograft Model Antitumor Assays
Title Patient-Derived Bladder Cancer Xenografts
URI https://www.ncbi.nlm.nih.gov/pubmed/28889386
Volume 1655
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