Patient-Derived Bladder Cancer Xenografts

Patient-derived xenograft (PDX ) tumors are models developed by direct transplant of human tumors into immune-compromised hosts such as nude mice. These models retain the histological and genetic characteristics of the primary tumor and are considered a valuable platform for translational cancer res...

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Bibliographic Details
Published inMethods in molecular biology (Clifton, N.J.) Vol. 1655; p. 169
Main Authors Bernardo, Carina, Santos, Lúcio Lara
Format Journal Article
LanguageEnglish
Published United States 2018
Subjects
Animals
Antineoplastic Agents - pharmacology
Disease Models, Animal
Drug Evaluation, Preclinical
Drug Screening Assays, Antitumor
Heterografts
Humans
Male
Mice
Urinary Bladder Neoplasms - drug therapy
Urinary Bladder Neoplasms - pathology
Xenograft Model Antitumor Assays
In vivo
Tumorgraft
Animal models
Xenograft
Bladder cancer
Drug testing
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Summary:Patient-derived xenograft (PDX ) tumors are models developed by direct transplant of human tumors into immune-compromised hosts such as nude mice. These models retain the histological and genetic characteristics of the primary tumor and are considered a valuable platform for translational cancer research. This chapter describes the methodology to establish and propagate bladder cancer PDX model.
ISSN:1940-6029
DOI:10.1007/978-1-4939-7234-0_14